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Abstract #3606

Cerebral Arterial & Venous Blood Volume Changes During the Post-Stimulus BOLD Undershoot Period

Tae Kim1, Soeng-Gi Kim1

1Neuroimaging Laboratory, Radiology, University of Pittsburgh, Pittsburgh, PA, United States

Sources of post-stimulus BOLD undershoots were investigated by measuring cerebral arterial and venous blood volume changes in isoflurane-anesthetized cats. After the cessation of 40-s visual stimulation, arterial CBV showed post-stimulus undershoots, similar to BOLD, while venous CBV returned to baseline slowly. Both CBF undershoot (due to arterial CBV undershoot) and slow venous CBV return contribute to the post-stimulus BOLD undershoot