Dietmar Cordes1, Mingwu Jin1,
1C-TRIC & Dept. of Radiology, University of Colorado-Denver, Aurora, CO, United States; 2Dept. of Psychology & Neuroscience, University of Colorado-Boulder, Boulder, CO, United States; 3Dept. of Neurology, University of Colorado-Denver, Aurora, CO, United States; 4Depts. of Biostatistic & Psychology, University of California-Los Angeles, Los Angeles, CA, United States
Focusing on activation in subregions of the medial temporal lobe (CA1, CA23DG, SUB, ERC, PRC, FUS, PHC) we used discriminant analysis applied to data from three different memory paradigms to investigate the degree of separation of the aMCI group from the normal control group as a function of the type of paradigm (outdoor pictures, faces-and-occupations, unrelated word pairs) and type of contrast (encoding-control, recognition-control, encoding-recognition, old-control, new-control, old-new). Results indicate optimum separation of groups for the face-and-occupation paradigm for contrast recognition-control. Prediction accuracy using the leave-one-out method is 75% using activations in left CA1, left SUB and left PHC.