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Abstract #3675

Alternating Phase Coherence of Spontaneous Hemodynamic Oscillation is Sensitive to Anesthesia Levels

Xiao Liu1, Xiao-Hong Zhu1, Yi Zhang1, Wei Chen1

1CMRR, Radiology, University of Minnesota, Minneapolis, MN, United States

In this study, we observed strong ~0.1 Hz hemodynamic (CBF and BOLD) oscillations in cats anesthetized with alpha-chloralose. The inter-hemispheric (i.e., left versus right V1, and left versus right LGN) phase coherence of hemodynamic oscillations is alternating between positive and negative values over time. Moreover, the relative proportions of positive and negative correlations changes with anesthesia level with more negative correlations under the deeper anesthesia. The results may suggest that the increased anesthesia level can impair the brains capability of synchronizing activity across different regions and result in less phase coherence even at the early thalamic brain regions.