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Abstract #3701

Monitoring of Iron-PLLA Particle Loaded MSCs After Intramuscular Injection in the Rat Model @ 3T

Volker Rasche1, Natalie Fekete2, Axel Bornstedt1, Jian Zhu, Ina Vernikouskaya, Martin Urban3, Katharina Landfester3, Gerlinde Schmidtke-Schrezenmeier2, Hubert Schrezenmeier2

1Internal Medicine II, University Hospital Ulm, Ulm, Germany; 2Institute for Transfusion Medicine, University Hospital Ulm; 3Max-Planck-Institute for Polymer Research

Recently the use of Poly-L-Lactic Acid (PLLA) iron loaded nanoparticles for MSC labeling was suggested. These particles were tested for in vivo monitoring of MSC trafficking in rats. The MSCs could be followed over 9 days in vivo with high sensitivitiy.