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Abstract #3709

In-Vivo Monitoring of Therapeutic Effects on Bacterial Infection using High-Field 19F-MRI

Volker Sturm1, Tobias Hertlein2, Thomas Christian Basse-Lsebrink1, Knut Ohlsen2, Peter Michael Jakob1

1Experimental Physics 5, University of Wrzburg, Wrzburg, Germany; 2Institute for Molecular Infection Biology, University of Wrzburg, Wrzburg, Germany

In the last few years, several methods have been developed to non-invasively monitor the time course of bacterial infections. In this context, MRI has proven its potential to image edema and infections by utilization of MR-markers. Perfluorocarbon (PFC) markers internalized by macrophages migrating to the site of inflammation allow background-free inflammation localization. The present study examined PFC markers to evaluate the efficacy of therapeutic measures in time course.