Thomas Christian Basse-Luesebrink1, Gesa Weise2, Carsten Wessig2, Peter Michael Jakob1, Guido Stoll2
1Experimental Physics 5, University of Wuerzburg, Wuerzburg, Bavaria, Germany; 2Neurology, University of Wuerzburg, Wuerzburg, Bavaria, Germany
Inflammatory cells play an important role in the pathophysiology disorders of the nervous system. Iron oxide-based contrast agents are commonly used to visualize neuroinflammation by magnetic resonance imaging (MRI). Unfortunately, local hemorrhages, blood pool effects and passive diffusion of iron oxide particles through a defective blood-nerve barrier can hamper the information gained.