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Abstract #3716

A Temperature Dependent Perfusion Rate Model for Simulating Temperature Evolution in Tissue for Magnetic Resonance Imaging Guided High Intensity Focused Ultrasound (MR-HIFU) Therapy: Initial Experience in a Pig Model

Jiming Zhang1, Pei-Herng Hor1, John Fischer2, Ari Partanen3, Tiina Karjalainen3, Raja Muthupillai2

1Department of Physics & Texas Center for Superconductivity, University of Houston, Houston, TX, United States; 2Diagnostic & Interventional Radiology, St. Luke's Episcopal Hospital, Houston, TX, United States; 3Clinical Science, Philips Medical Systems, Cleveland, OH, United States

We propose a theoretical model utilizing a temperature dependent perfusion term for simulating the temperature evolution during and following MR-HIFU therapy in a pig model. The results from the theoretical model match closely with experimental observations. Key insights from our study are the following: (a) Local tissue perfusion responses in MR-HIFU are much dynamic than what has been reported in hyperthermia applications; (b) A temperature dependent perfusion term is necessary for adequately modeling the temperature evolution in MR-HIFU, and (c) Tissue perfusion response to MR-HIFU must be taken into account in clinical HIFU therapy planning and optimization