Abstract #3717

Real-Time Monitoring of Temperature & Magnetization Transfer During HIFU Transmission & Long-Term Follow-Up of Magnetization Transfer Effect : In Vivo Rabbit Investigations

Hsu-Hsia Peng¹, Teng-Yi Huang², Wei-Min Tseng², Yu-Hui Ding³, Hsiao-Wen Chung⁴, Wen-Shiang Chen³, Wen-Yih Isaac Tseng⁵

¹Dept. of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; ²Department of Electrical Engineering, National Taiwan University of Science & Technology, Taipei, Taiwan; ³Department of Physical Medicine & Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan; ⁴Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan; ⁵Center for Optoelectronic Biomedicine, Medical College of National Taiwan University, Taipei, Taiwan

An imaging sequence, which simultaneously monitors temperature change and magnetization transfer (MT) contrast, was applied on in vivo rabbit thigh muscle during HIFU sonicaiton. After sonication, T2WI, FLAIR images, and 3D MT images were acquired for long-term investigations of heated region. On the MTR maps, the surrounded tissue with low MTR delineates clearly the extent of heated region, underlining the advantage of long-term follow-up with usage of MT effect. In conclusion, real-time monitoring of temperature and MT mapping during HIFU sonication is an effective technique to evaluate the long-term follow-up of tissue damage following HIFU treatment.