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Abstract #3727

Assessing Thermal Tissue Damage with Biexponential Diffusion-Weighted MRI

Valentina Giannini1,2, Pejman Ghanouni3, Graham Sommer3, Chris Diederich4, Andrew Holbrook3, Vasant Salgaonkar4, Punit Prakash4, Harcharan Gill5, Donna Bouley6, Kim Butts Pauly3

1Radiology, FPRC, Candiolo, TO, Italy; 2Radiology, Stanford University, Stanford, Ca, United States; 3Radiology, Stanford University, Stanford, CA, United States; 4Radiation Oncology, University of California, San Francisco, San Francisco, Ca, United States; 5Urology, Stanford University, Stanford, CA, United States; 6Comparative Medicine, Stanford University, Stanford, CA, United States

In this study, we want to assess the use of DWI images to estimate prostate tissue damage during HIFU ablation, by measuring diffusion coefficients of canine prostate pre and post ablated, using multiple b-factors ranging up to 3500 s/mm2. EPI DWI images were collected before and after the ablation, with 12 different b values from 0 to 3500 s/mm2, and with a tetrahedral encoding scheme. This study demonstrates changes in the fast and slow diffusion rates and fractions after thermal ablation. In addition, differences in the diffusion rates in heat fixed vs. non-heat fixed ablated tissue are demonstrated.