Meeting Banner
Abstract #3728

Comparing Different Drug Carriers for Dynamic Absolute MR Thermometry

Roel Deckers1, Sara M. Sprinkhuizen1, Marina Talelli2, Bart Crielaard2, Hans Ippel3, Rolf Boelens3, Twan Lammers2,4, Chris J. Bakker1, Gert Storm2, Lambertus W. Bartels1

1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands; 3Department of NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, Netherlands; 4Department of Experimental Molecular Imaging, RWTH Aachen, Aachen, Germany

Dynamic absolute MR thermometry may be of great interest for the precise and accurate control of hyperthermia in local drug delivery applications. We compared different drug carriers that provide a temperature insensitive proton resonance frequency (PRF) that can serve as reference for the temperature sensitive PRF of water. The frequency difference between both PRFs is a measure of the absolute temperature and can be measured with NMR spectroscopy or multi-Gradient Echo (mGE) sequence. The influence of the drug carrier composition and the pH on the NMR signal are measured and the accuracy and sensitivity of the mGE method are investigated.