Roel Deckers1, Sara M. Sprinkhuizen1,
1Image Sciences Institute, University Medical Center Utrecht, Utrecht, Netherlands; 2Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands; 3Department of NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Utrecht University, Utrecht, Netherlands; 4Department of Experimental Molecular Imaging, RWTH Aachen, Aachen, Germany
Dynamic absolute MR thermometry may be of great interest for the precise and accurate control of hyperthermia in local drug delivery applications. We compared different drug carriers that provide a temperature insensitive proton resonance frequency (PRF) that can serve as reference for the temperature sensitive PRF of water. The frequency difference between both PRFs is a measure of the absolute temperature and can be measured with NMR spectroscopy or multi-Gradient Echo (mGE) sequence. The influence of the drug carrier composition and the pH on the NMR signal are measured and the accuracy and sensitivity of the mGE method are investigated.