Abstract #3902

Construction of a Model-Based High Resolution Arterial Input Function (AIF) using a Standard Radiological AIF & the Levenberg-Marquardt Algorithm

Hassan Bagher-Ebadian^1,2, Azimeh Noorizadeh³, Siamak P. Nejad-Davarani^1,4, Ramesh Paudyal¹, Tavarekere N. Nagaraja⁵, Robert Knight^1,2, Stephen Brown⁶, Joseph D. Fenstermacher⁵, James R. Ewing^1,2

¹Neurology, Henry Ford Hospital, Detroit, MI, United States; ²Physics, Oakland University, Rochester, MI, United States; ³Mechanical Engineering, Nuclear Engineering, University of Shiraz, Shiraz, Fars, Iran; ⁴Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States; ⁵Anesthesiology, Henry Ford Hospital, Detroit, MI, United States; ⁶Radiation Oncology, Henry Ford Hospital, Detroit, MI, United States

Estimating the arterial input function of a contrast agent (CA), the time-concentration curve in plasma, has long presented a problem in MR dynamic contrast Enhanced and dynamic susceptibility studies. A successful model based on the blood-circulatory system for the construction of an algorithm for estimating the CA time-concentration curve in arterial plasma has been previously suggested. A set of time courses of radiolabeled-Gd-DTPA CA-concentrations in arterial plasma (timeactivity curve) of 13 animals has been recently measured. Herein, the radiolabeled-time-concentration curve was used to estimate a set of parameters for constructing a blood-circulatory model AIF in a high temporal resolution.