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Abstract #3914

Utility of Non-Model Based Semi-Quantitative Indices Derived from Dynamic Contrast Enhanced T1-Weighted MR Perfusion in Differentiating Treatment Induced Necrosis from Recurrent Progressive Brain Tumor.

Jayant Narang1, Rajan Jain1,2, Syed Ali Arbab3, Abbas Babajani-Feremi3

1Neuroradiology, Henry Ford Health System, Detroit, MI, United States; 2Neurosurgery, Henry Ford Health System, Detroit, MI, United States; 3Radiology, Henry Ford Health System, Detroit, MI, United States

The purpose of this study was to assess the utility of non-model based semi-quantitative indices derived from dynamic contrast-enhanced T1-weighted magnetic resonance perfusion (DCET1MRP) in differentiating treatment induced necrosis (TIN) from recurrent/progressive tumor (RPT). Practical impact of DCET1MRP on routine neuro-oncologic imaging practice is limited by the need of complicated multi-compartment physiological models and intensive computational requirements to derive pharmacokinetic metrics and hence, the lack of an easy to use commercially available software. Our results show that these non-model based indices which are relatively easy to derive, robust and reproducible can be effectively used to differentiate TIN from RPT.