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Abstract #3941

Robustness of Echo Planar Imaging (EPI) Distortion Correction in Diffusion Tensor Imaging using Forward/reverse Phase Encode Directional B=0 Scans

Wanyong Shin1, Erik B. Beall1, Ken Sakaie1, Mingyi Li1, Dominic Holland2, Anders M. Dale3, Mark Lowe1

1Radiology, Imaging Institute, Cleveland Clinic, Cleveland, OH, United States; 2Neuroscience, University of California, San Diego, CA, United States; 3Radiology, University of California, San Diego, CA, United States

Recently, Holland et al. (Neuroimage, 2010) presented a fast, highly computationally efficient unwarping method using forward and reverse phasing encode (PE) directional EPI scans. In this study, we propose a single diffusion tensor imaging (DTI) scan in which a forward / reverse PE direction scan with b = 0 is implemented as a first acquisition. We test the reproducibility and robustness of the proposed unwarping technique from voxel-wise fractional anisotropy comparison using the proposed DTI sequence.