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Abstract #3963

Voxel-Based Morphometric Analysis of Fiber Tract Volume of Corpus Callosum using Large Deformation Diffeomorphic Metric Mapping & Diffusion Spectrum Tractography

Hsiao-Chin Cheng1, Yung-Chin Hsu2, Wen-Yih Isaac Tseng1,3

1Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 2Department of Biomedical Engineering & Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan; 3Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

We normalized diffusion spectrum imaging data sets, acquired from 7 males and 7 females, to a template using 6D Large Deformation Diffeomorphic Metric Mapping (LDDMM) algorithm. Voxel-based analysis was performed to compute the gender difference in tract volume of the corpus callosum. The males tract volume was generally larger than the females, but there was a spatial variation in the difference. The most prominent difference was found in frontal and temporal lobes, whereas little difference was found in parietal and occipital lobes. Our study demonstrates the feasibility of 6D LDDMM in the analysis of tract volume using voxel-based morphometric approach.