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Abstract #4000

Coupling between Resting Cerebral Perfusion & EEG Power

Lars Michels1, Ernst Martin1, Daniel Brandeis2, Rafael Lchinger2, Peter Klaver3, Ajit Shankaranarayanan4, David C. Alsop5,6, Ruth L. O'Gorman1

1University Children's Hospital, Zrich, Switzerland; 2Department of Child & Adolescent Psychiatry, University of Zrich, Zrich, Switzerland; 3Department of Psychology, University of Zrich, Zrich, Switzerland; 4Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 5Beth Israel Deaconess Medical Center, Boston, MA, United States; 6Harvard Medical School, Boston, MA, United States

This study examines the relationship between resting EEG power fluctuations in low, medium, and high frequency bands and resting cerebral perfusion. EEG and ASL data were acquired in separate measurement sessions in a group of 12 healthy adults. Peak EEG power correlated positively with perfusion in a widespread network including both cortical and sub-cortical regions. After controlling for whole-brain ASL perfusion, significant correlations were restricted to a smaller network of regions, and predominantly negative correlations were found for alpha frequencies, whereas higher frequencies (gamma) exhibited predominantly positive correlations.