Abstract #4000

Coupling between Resting Cerebral Perfusion & EEG Power

Lars Michels¹, Ernst Martin¹, Daniel Brandeis², Rafael Lchinger², Peter Klaver³, Ajit Shankaranarayanan⁴, David C. Alsop^5,6, Ruth L. O'Gorman¹

¹University Children's Hospital, Zrich, Switzerland; ²Department of Child & Adolescent Psychiatry, University of Zrich, Zrich, Switzerland; ³Department of Psychology, University of Zrich, Zrich, Switzerland; ⁴Global Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; ⁵Beth Israel Deaconess Medical Center, Boston, MA, United States; ⁶Harvard Medical School, Boston, MA, United States

This study examines the relationship between resting EEG power fluctuations in low, medium, and high frequency bands and resting cerebral perfusion. EEG and ASL data were acquired in separate measurement sessions in a group of 12 healthy adults. Peak EEG power correlated positively with perfusion in a widespread network including both cortical and sub-cortical regions. After controlling for whole-brain ASL perfusion, significant correlations were restricted to a smaller network of regions, and predominantly negative correlations were found for alpha frequencies, whereas higher frequencies (gamma) exhibited predominantly positive correlations.