Non Contrast 3D Volumetric Time-Resolved MRA Combining Multiple Phase FAIR(CINEMA-FAIR)

Masanobu Nakamura¹, Masami Yoneyama¹, Tomoyuki Okuaki¹, Takashi Tabuchi¹, Atsushi Takemura², Makoto Obara², Junko Ogura¹, Satoshi Tsutsumi³

Detailed information on anatomy and hemodynamics in cerebrovascular disorders such as AVM and Moyamoya disease is mandatory for defined diagnosis and treatment planning. Currently most widely used non-contrast MRA techniques are TOF and PC. Those non-contrast techniques are, however, mostly limited to a single frame images. Recently we have proposed 3D volumetric non contrast time-resolved MRA technique termed Contrast inherent inflow enhanced multi phase angiography combining multiple phase FAIR (CINEMA-FAIR). CINEMA technique combines ASL with 3D segmented T1 weighted gradient echo sequence (3D T1 TFE). FAIR preparation scheme with the Look-Locker sampling was used for spin tagging in this study. CINEMA could extract the blood flow in the whole brain at an interval of 100 ms and thus permitted us to observe vascular construction in full by preparing MIP images. This preliminary study demonstrated the usefulness of CINEMA-FAIR technique in evaluating the cerebral vascularture.