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Abstract #4056

Age-Related Differences in Metabolites in the Posterior Cingulated Cortex & Hippocampus of Normal Ageing Brain: A 1H-MRS Study

Harmen Reyngoudt1,2, Tom Claeys1,2, Leslie Vlerick1,2, Stijn Verleden3, Marjan Acou1,2, Karel Deblaere1,2, Yves De Deene4, Kurt Audenaert3, Ingeborg Goethals1, Eric Achten1,2

1Radiology & Nuclear Medicine, Ghent University, Ghent, Belgium; 2Ghent Institute for Functional & Metabolic Imaging, Ghent University, Ghent, Belgium; 3Psychiatry & Medical Psychology, Ghent University, Ghent, Belgium; 44Laboratory for Quantitative & Nuclear Magnetic Resonance in Medicine & Biology, Ghent University, Ghent, Belgium

Ageing is a diverse process, associated with a progressive, yet variable, decline of cognitive abilities. In neurodegenerative disorders such as Alzheimers disease (AD) and mild cognitive impairment (MCI), metabolic abnormalities have been observed in the posterior cingulated cortex (PCC) and the hippocampus (HC). healthy subjects (42 women and 48 men aged 18-76 years, mean SD, 48.4 16.8 years) were studied with 1H-MRS. Metabolite ratios