Abstract #4056

Age-Related Differences in Metabolites in the Posterior Cingulated Cortex & Hippocampus of Normal Ageing Brain: A 1H-MRS Study

Harmen Reyngoudt^1,2, Tom Claeys^1,2, Leslie Vlerick^1,2, Stijn Verleden³, Marjan Acou^1,2, Karel Deblaere^1,2, Yves De Deene⁴, Kurt Audenaert³, Ingeborg Goethals¹, Eric Achten^1,2

¹Radiology & Nuclear Medicine, Ghent University, Ghent, Belgium; ²Ghent Institute for Functional & Metabolic Imaging, Ghent University, Ghent, Belgium; ³Psychiatry & Medical Psychology, Ghent University, Ghent, Belgium; ⁴4Laboratory for Quantitative & Nuclear Magnetic Resonance in Medicine & Biology, Ghent University, Ghent, Belgium

Ageing is a diverse process, associated with a progressive, yet variable, decline of cognitive abilities. In neurodegenerative disorders such as Alzheimers disease (AD) and mild cognitive impairment (MCI), metabolic abnormalities have been observed in the posterior cingulated cortex (PCC) and the hippocampus (HC). healthy subjects (42 women and 48 men aged 18-76 years, mean SD, 48.4 16.8 years) were studied with 1H-MRS. Metabolite ratios