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Abstract #4057

Aging Effect on the Resting State: Two Complementary Approaches with the Same fMRI Datasets

Makoto Miyakoshi1, Satoru Miyauchi2, Takahiko Koike2, Shigeyuki Kan2, Toshiharu Nakai1

1National Center for Geriatrics & Gerontology, Ohbu, Aichi, Japan; 2National Institute of Information & Communications Technology, Japan

The present study aimed to investigate the aging brain with two different approaches, the alpha-power correlation and functional connectivity by simultaneous EEG-fMRI recording. Extracting alpha band activity with temporal ICA on EEG was successful with the young but not with the old. Alpha-power correlated regions of the young thus suggest regions that are subject to age-related changes, which is probably due to degeneration of temporal organization of alpha-band activity. Functional connectivity analyses identified the corresponding network in the old, whose spatial pattern is nonetheless altered to be diffusive. This alternation may be responsible for the emissingf alpha-band activity.