Abstract #4059

On the Feasibility of Reduced Dose Dynamic Susceptibility Contrast Perfusion MRI for Stroke

Jeffry R. Alger^1,2, T. J. Schaewe, D. S. Liebeskind, J. L. Saver, C. S. Kidwell³

¹Neurology, Geffen School of Medicine at UCLA, Los Angeles, CA, United States; ²Radiological Sciences, Geffen School of Medicine at UCLA, Los Angeles, CA, United States; ³Neurology, Georgetown University, Washington, DC, United States

The feasibility of half dose (0.05 mmol/kg) DSC microvascular perfusion MRI for stroke evaluation was assessed in normal subjects and by computer simulation under conservative 1.5 T imaging conditions. Results suggest that half dose DSC is feasible. This suggests the possibility reduced gadolinium exposure in routine stroke imaging and clinical trials that use MRI for assessment of stroke therapy.