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Abstract #4060

Prediction of Hemorrhagic Transformation in Acute Ischemic Stroke using DCE MRI: Delayed AUC Measures Versus Quantitative Estimates of Permeability

Alexis Gordon1, Jackie Leung2, Igor Sitartchouk1, David Mikulis3, Andrea Kassner1

1Medical Imaging, University of Toronto, Toronto, Ontario, Canada; 2Diagnostic Imaging, the Hospital for Sick Children, Toronto, Ontario, Canada; 3Medical Imaging, Toronto Western Hospital, Toronto, Ontario, Canada

Hemorrhagic transformation (HT) is a major adverse outcome of acute ischemic stroke. Accurate methods for predicting HT would improve patient care and stratify risk when directing treatment. Quantitative permeability estimates, KPS, are able to predict HT but require an arterial input function and kinetic modelling. Alternatively, semi-quantitative measures such as the initial area under the curve (IAUC) can provide a fast surrogate measure of KPS. However, it is not known what the optimal time interval is to associate AUC with risk of HT. Our study showed that a delayed AUC from 50-140 s is superior to a previously reported IAUC.