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Abstract #4105

Creation & Validation of a White Matter Importance Map using Traumatic Brain Injury Patient Data

Amy Kuceyeski1, Ashish Raj1

1Radiology, Weill Cornell Medical College, New York, NY, United States

Brain diseases such as stroke, multiple sclerosis and traumatic brain injury result in various levels of disability, depending on the affected areas location and size. We propose a computational methodology that assigns quantitative scores to the decrease in brain connectivity resulting from regional damage via a quantitative importance map of the brain. We use image data and clinical measures such as Attention Network Test (ANT) and California Verbal Learning Test (CVLT) in a set of patients with traumatic brain injury to show that correlations between image information and clinical measures improve to levels of significance when including importance map information.