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Abstract #4106

Neuromelanin Imaging in Dementia with Lewy Body (DLB)

Masahiro Ida1, Shunsuke Sugawara1, Yuko Kubo1, Keiko Hino1, Naoya Yorozu1, Tomohiro Suzuki1, Shuzo Ikuta1, Yuko Kawaguchi1

1Department of Radiology, Tokyo Metropolitan Ebara Hospital, Oota-ku, Tokyo, Japan

The purpose of this study was to compare the alteration of the neuromlanin (NM) signal in the substantia nigra (SN) and locus ceruleus (LC) of dementia with Lewy body (DLB) patients with that of PD and AD patients and normal controls (NC) to elucidate the clinical significance at 3T. NM imaging can detect signal reduction in the SN and LC which indicates alterations in the NM concentration and catecholaminergic neurons. The NM signals of the SN and LC in DLB were lower than normal subjects and AD. NM signal intensity in DLB was decreased to the same degree as PD patients. NM imaging is a helpful tool to distinguish DLB from AD in diagnosing patients with dementia.