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Abstract #4108

Concordant Brain Structural & Diffusion Changes in Frontotemporal Dementia with & without Motor Neuron Disease

Yu Zhang1,2, Norbert Schuff1,2, Maria Carmela Tartaglia2, Joel Laxamana1,2, Howard J. Rosen2, Maria Luisa Gorno-Tempini2, Bruce L. Miller2, Michael W. Weiner1,3

1Center for Imaging of Neurodegenerative Diseases, VA Medical Center, San Francisco, CA, United States; 2University of California, San Francisco, San Francisco, CA, United States; 3University California, San Francisco, CA, United States

Frontotemporal dementia (FTD) with syndromes of motor neuron disease (FTD/MND) is a subtype of FTD that involves neurons controlling voluntary movement. Clinical and neuroimaging studies revealed overlaps between FTD and FTD/MND but their differences were unknown. This study aimed to evaluate these differences in concordant variations of regional atrophy and mean diffusivity (MD) changes of gray (GM), and concordant variations of regional atrophy and fractional anisotropy (FA) changes of white matter (WM). The findings of that FTD/MND had severer concordant GM damages than FTD reflected that the neuropathological features of FTD/MND are different to FTD syndromes without MND.