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Abstract #4109

DTI Reveals Abnormal White Matter Pathways to Classic Language Areas in Semantic Dementia

Julio Acosta-Cabronero1, Karalyn Patterson1, Tim D. Fryer1, John R. Hodges2, George Pengas1, Guy B. Williams1, Peter J. Nestor1

1Department of Clinical Neurosciences, University of Cambridge, Cambridge, Cambridgeshire, United Kingdom; 2Neuroscience Research Australia, Randwick, Australia

Using tract-based spatial statistics, we compared diffusion tensor data from 10 semantic dementia (SD) patients and 21 controls. Abnormalities in all metrics were highly statistically significant in ventro-rostral temporal white matter, more extreme on the left side. To examine more remote changes, we performed an average-control tractographythree major neural pathways were found to emanate from the lesion: uncinate (UF), arcuate (AF) and inferior longitudinal fasciculi (ILF). At a less conservative threshold, tensor abnormalities in the SD group mapped onto the tractography for the UF and AF well beyond the rostral temporal lobe; but not further caudally along the ILF.