Abstract #4110

Cranio Spinal Hydrodynamic View of Neurodegenerative Disease by 2D-PCMRI

Olivier Baldent¹, Soraya El Sankari², Catherine Gondry-Jouet³, Anthony Fichten⁴, Olivier Pottie¹, Roger Bouzerar¹, Jean-Marie Serot⁵, Olivier Godefroy², Herv Deramond³, Marc-Etienne Meyer¹

¹Image Processing, University Hospital Jules Verne, Amiens, Picardie, France; ²Neurology, University Hospital Jules Verne, Amiens, Picardie, France; ³Radiology, University Hospital Jules Verne, Amiens, Picardie, France; ⁴Neurosurgery, University Hospital Jules Verne, Amiens, Picardie, France; ⁵Geriatry, University Hospital Jules Verne, Amiens, Picardie, France

Our purpose was to evaluate PC-MRI on intracranial flows in Mild Cognitive Impairment (MCI) and Alzheimer Disease (AD). Patients underwent 3T MRI with 2D Phase Contrast (2D-PCMRI) pulse sequences to evaluate CSF oscillations and cerebral blood flows. Results were compared to normal values in age matched elderly healthy volunteers, and to Chronic Adult Hydrocephalus (CAH) patients. Arterial flow was significantly increased in MCI patients. Aqueductal CSF flow was normal in AD, hyper dynamic in MCI patients but less than in CAH patients. In conclusion this study highlights the interest of 2D-PCMRI and supports the vascular theory of AD pathophysiology