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Abstract #4112

Evaluation of T1 & T2* Mapping Reproducibility at 3T using Histogram Analysis

Christopher Glielmi1, Ryan Hutten2, Shawn Sidharthan2, Hongyan Du2, Todd Parrish3, Ann Ragin4, Robert R. Edelman2, Ying Wu2

1Cardiovascular MR R&D, Siemens Healthcare, Chicago, IL, United States; 2NorthShore University HealthSystem, Evanston, IL, United States; 3Biomedical Engineering, Northwestern University, Chicago, IL, United States; 4Radiology, Northwestern University, Chicago, IL, United States

T1 and T2* mapping are useful approaches to detect and monitor degenerative brain diseases such as Parkinson's disease (PD) and Alzheimer's disease (AD). However, reproducibility between repeated measures must be evaluated for clinical studies involving serial scanning. This study explores reliability and reproducibility of various histogram analysis metrics for T1 and T2* mapping in healthy subjects at 3T. Specifically, focus is on subcortical regions relevant to neurodegenerative diseases such as PD and AD.