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Abstract #4113

Reproducibility of Apparent Diffusion Coefficient Values at Hippocampus Measured by High-Resolution Readout-Segmented DWI vs. Single-Shot DWI with 2DRF Excitations.

Ryo Sakamoto1, Tomohisa Okada1, Akira Yamamoto1, Mitsunori Kanagaki1, Seiko Kasahara1, Emiko Morimoto1, Mami Iima1, Satoshi Nakajima1, Taha Mohammed Mehemed1, Kaori Togashi1

1Diagnostic Imaging & Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

Clinical applications of ADC measurement for disorders involving hippocampus are highly important. It requires reasonable reproducibility in acceptable scan time. In single-shot EPI, 2D-RF excitations enables reduced FOV, and less distorted DWI (2DRF-DWI) can be obtained. For multi-shot EPI, readout-segmented EPI can be used for DWI measurement (RS-DWI). These two methods gave highly reproducible CV values of ADC: 1.82 } 1.12 and 2.42 } 1.36 %, respectively for RS-DWI and 2DRF-DWI. However, ADC values at hippocampus were 0.881} 0.027~10-3 mm2/s and 0.463 } 0.039~10-3 mm2/s, respectively, and the latter resulted from low SNR in 2DRF-DWI.