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Abstract #4114

A Multimodal MRI Investigation in Patients with Alzheimers Disease, Mild Cognitive Impairment, & Cognitively Normal Subjects

Sun Mi Kim1, Min Ji Kim1, Chang-Woo Ryu1, Eui Jong Kim2, Woo Suk Choi2, Geon-Ho Jahng1, Dal-Mo Yang1

1Radiology, Kyung Hee University Hospital-Gangdong, Seoul, Korea, Republic of; 2Radiology, Kyung Hee University Hospital, School of Medicine, Kyung Hee University, Seoul, Korea, Republic of

We prospectively evaluate if the gray matter(GM) loss, the diffusion aniotropic change, the cerebral perfusion reduction demonstrate a pattern of concordance or dissociation in subjects with AD, MCI, compared with cognitively normal(CN) subjects. 3D isotrophic T1WI, DT-MRI, and pulsed ASL were obtained in 26 AD, 26 MCI, and 26 CN subjects. Multimodal investigations can demonstrate the pattern of concordance or dissociation in patients with AD and MCI. Concordance areas of GM loss, the diffusion change, and perfusion reduction were mainly in the temporal lobes, the cingulum, and the parietal lobes.