Min-Ji Kim1,2, Geon-Ho Jahng1,
Hyck-Gi Kim1, Sun-Mi Kim1, Chang-Woo Ryu1,
Dal-Mo Yang1, Hack-Young Lee3, Won-Chul Shin3,
Dong- Kyun Lee4, Jong-Min Lee4
1Department of Radiology,
Kyung Hee University Hospital-Gandong, Kyung Hee University, Seoul, Korea,
Republic of; 2East-West Neo Medical Center Kyung Hee Huiversity,
Seoul, Korea, Democratic People's Republic of; 3Department of
Neurology, Kyung Hee University Hospital-Gandong, Kyung Hee University,
Seoul, Korea, Republic of; 4Department of Biomedical Engineering,
Hanyang University, Seoul, Korea, Republic of
To investigate regional shape differences of hippocampus through automated hippocampal segmentation in healthy aging (CN), amnestic mild cognitive impairment (MCI), and Alzheimers disease (AD), a three-dimensional T1-weighted imaging (i.e. MPRAGE) sequence was run in subjects with 26 MCI, 26 probable AD, and 26 HC. A fully automated hippocampal segmentation method was used for reconstructing three dimensional hippocampal shapes in each subject. The result showed a regional pattern of shape difference between normal control and amnestic MCI, more evident for inward deviation of lateral zone of the hippocampus, which intersects the area of the hippocampus containing the CA1 region.
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