Vincent Dor1, Jurgen Fripp1, Pierrick Bourgeat1, Oscar Acosta1,2, Olivier Salvado1
1Biomedical Imaging ICT, the
Australian e-Health Research Centre, CSIRO,
MR imaging has been widely used to highlight the brain changes occurring in neurodegenerative diseases by comparing affected patients to healthy individuals. However, only few studies focus on contrast changes between gray matter (GM) and white matter (WM). To our knowledge, no longitudinal study of tissue intensities has been reported. We hypothesize that tissue alteration as measured by WM/GM could provide insights into the etiology of Alzheimers disease (AD). We investigate the longitudinal evolution of the contrast using a new tissue normalisation method. The MRI intensity normalisation enable to measure significant change in contrast between AD patient and healthy elder.