Resting State Functional Connectivity Correlated with Neuropsychological Tests in Temporal Lobe Epilepsy Patients

Martha J. Holmes^1,2, John C. Gore^1,2, Brad S. Folley³, Bassel Abou-Khalil³, Hasan H. Sonmezturk³, Victoria L. Morgan^1,2

Temporal lobe epilepsy (TLE) patients typically have memory deficits from structural damage to the left hippocampus (LH). The objective of our analysis is to identify regions whose resting state connectivity to the LH is correlated to a verbal memory retrieval neuropsychological test in TLE patients. We found a region in the left insula that showed increased connectivity to the LH with increased memory scores, and a region in the left limbic lobe region whose connectivity to LH decreased with increased memory scores. These results suggest a possible compensatory mechanism to overcome these memory deficits in TLE.