Functional Activation Within Hippocampal Subfields During Scene Memory Encoding in Temporal Lobe Epilepsy

Sandhitsu Das¹, Dawn Mechanic-Hamilton², Marc Korczykowski², John Pluta¹, John Detre², Paul Yushkevich¹

We report, for the first time, patterns of functional activation in hippocampal subfields in a cohort of temporal lobe epilepsy patients and healthy controls during a complex scene memory encoding task. We detect group differences in activation between controls and patients, with higher activation in controls and in patients' non-epileptogenic side than patients' epileptogenic side, with the greatest effects in dentate gyrus (DG) and in anterior hippocampus. DG is also found to be more active than CA1 in controls, but not in patients.