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Abstract #4153

Morphometric & Functional Connectivity Correlates of Hippocampal Changes in Migraine Frequency

Nasim Maleki1, Gautam Pendse1, Lauren Nutile2, Rami Burstein3, Lino Becerra1,4, David Borsook1

1P.A.I.N. Group, Brain Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA, United States; 2Department of Psychology, Villanova University, Villanova, PA, United States; 3Department of Anesthesia & Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA; 4Department of Radiology, Massachusetts General Hospital, Charlestown, MA

The role of the hippocampus in migraine has not been well characterized. In this study we assessed whether there are any anatomical changes in the hippocampus in migraine patients based on the frequency of their migraine attacks and what the corresponding functional connectivity correlates are.