Suk-Tak Chan1, Ka-Yue Chan2, Sau-Fan Ma2, Shuk-Ling Law2, Shuk-Yee Ho2, Hiu-Kwan Lee2, Kwok-Wing Tang3, Andrew Kwok-cheung Lam4, James Yuk-ling Cheung3, Kenneth K. Kwong1
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States; 2Department of Health Technology & Informatics, the Hong Kong Polytechnic University, Hong Kong; 3Department of Diagnostic Radiology & Imaging, Queen Elizabeth Hospital, Hong Kong; 4School of Optometry, the Hong Kong Polytechnic University, Hong Kong
The functional interactions among brain regions in the network for saccadic eye movements would provide information on how the strabismic brains adapt to the visual deficits. Context-dependent correlation approach was used to study the functional connectivity for saccadic eye movements in both strabismic and healthy brains. Dominant negative correlations were demonstrated in strabismic brains relative to healthy brains. The connectivity findings imply the possible modulation of the functional connectivity for saccadic eye movements in a complicated network of brain regions in the frontal, supplementary, parietal and occipital eye fields, and midbrain of strabismic adults.