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Abstract #4171

Neurochemical Profile in the Hippocampus of Aging Mice as Detected by In Vivo 1H NMR Spectroscopy at 14.1T

Joao M. N. Duarte1,2, Rolf Gruetter1,3

1Laboratory for Functional & Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique, Lausanne, Vaud, Switzerland; 2Faculty of Biology & Medicine, University of Lausanne, Lausanne, Switzerland; 3Department of Radiology, Universities of Lausanne & Geneva, Lausanne, Switzerland

The concentration of metabolites in different cerebral areas, so called neurochemical profile, can be taken as biomarker of regional development, differentiation or degeneration. Aging-associated functional alterations may be accompanied by neurochemical alterations that were now evaluated in aging mice, using in vivo proton spectroscopy at 14.1 T.