Joao M. N. Duarte1,2, Rolf Gruetter1,3
1Laboratory for Functional
& Metabolic Imaging, Center for Biomedical Imaging, Ecole Polytechnique,
Lausanne, Vaud, Switzerland; 2Faculty of Biology & Medicine,
University of Lausanne, Lausanne, Vaud, Switzerland; 3Departments
of Radiology, Universities of LAusanne & Geneva
The combination of dynamic 13C NMR spectroscopy with the infusion of 13C-enriched substrates is a powerful method to probe metabolic fluxes in vivo. The increase in magnetic field opens the opportunity for gain in sensitivity and spectral resolution, which was now explored to study brain metabolism.