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Abstract #4187

Correlating Longitudinal & Quantitative MRI Metrics Elucidates White Matter Changes in the Cuprizone Mouse Model of Demyelination

Jonathan Dale Thiessen1, Yanbo Zhang2, Handi Zhang2, Lingyan Wang2, Richard Buist3, Jiming Kong4, Xin-Min Li2, Melanie Martin5,6

1Physics & Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada; 2Psychiatry, University of Manitoba; 3Radiology, University of Manitoba; 4Human Anatomy & Cell Science, University of Manitoba; 5Physics & Astronomy/Radiology, University of Manitoba; 6Physics, University of Winnipeg

To understand the interplay different MRI methods have as white matter changes longitudinally in the cuprizone mouse model, in vivo T2-weighted and magnetization transfer images (MTI) were acquired weekly in control and cuprizone-fed mice. As well, diffusion tensor imaging, quantitative MTI, T1/T2 relaxometry, T2-weighted imaging, and histopathology were used to analyze ex vivo tissue after 6 weeks of cuprizone delivery. Correlation between both longitudinal and quantitative datasets was measured with a focus on the corpus callosum. Ultimately, correlation of both longitudinal and quantitative MRI metrics may help elucidate white matter changes beyond the application of individual MRI methods.