Abstract #4187

Correlating Longitudinal & Quantitative MRI Metrics Elucidates White Matter Changes in the Cuprizone Mouse Model of Demyelination

Jonathan Dale Thiessen¹, Yanbo Zhang², Handi Zhang², Lingyan Wang², Richard Buist³, Jiming Kong⁴, Xin-Min Li², Melanie Martin^5,6

¹Physics & Astronomy, University of Manitoba, Winnipeg, Manitoba, Canada; ²Psychiatry, University of Manitoba; ³Radiology, University of Manitoba; ⁴Human Anatomy & Cell Science, University of Manitoba; ⁵Physics & Astronomy/Radiology, University of Manitoba; ⁶Physics, University of Winnipeg

To understand the interplay different MRI methods have as white matter changes longitudinally in the cuprizone mouse model, in vivo T₂-weighted and magnetization transfer images (MTI) were acquired weekly in control and cuprizone-fed mice. As well, diffusion tensor imaging, quantitative MTI, T₁/T₂ relaxometry, T₂-weighted imaging, and histopathology were used to analyze ex vivo tissue after 6 weeks of cuprizone delivery. Correlation between both longitudinal and quantitative datasets was measured with a focus on the corpus callosum. Ultimately, correlation of both longitudinal and quantitative MRI metrics may help elucidate white matter changes beyond the application of individual MRI methods.