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Abstract #4186

Efficacy of Ginkgo Biloba in Aluminium Induced Neurotoxicity on Rat Brain: Magnetization Transfer & Diffusion Weighted MRI Study

Shatakshi Srivastava1, Sandeep Tripathi2, Abbas Ali Mahdi2, Raja Roy1

1Centre of Biomedical Magnetic Resonance, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India; 2Department of Biochemistry, Chatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, India

Aluminium is known to cause neurotoxicity in terms of cognitive decline and the patients undergoing regular dialysis are at a high exposure risk to this metal ion. It results in neurofibrilar degeneration significantly similar to the Alzheimers Disease (AD). Therefore, in the present study, efficacy of herbal extracts obtained from Ginkgo biloba (GB), a known neuro-protective agent have been investigated on aluminum induced neurodegenerative changes in rats brain using in vivo MT-MRI and DWI. The study demonstrates effective therapeutic role of GB against Aluminium induced neurotoxicity.