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Abstract #4197

Multiparametric Imaging of Rat Glioma after Intra Tumoral Injection of Codbait, a Small Molecule Mimicking Dna Damage for Sensitizing Tumors to Radiotherapy

Nicolas Coquery1,2, Nicolas Pannetier1,2, Rgine Farion1,2, Didier Clarencon3, Jian-Sheng Sun4, Marie Dutreix4, Emmanuel Luc Barbier1,2, Chantal Rmy1,2

1Grenoble Institute of Neuroscience, Grenoble, France; 2Universit Joseph Fourier, Grenoble, France; 3Centre de Recherches du Service de Sant des Armes, La Tronche, France; 4Institut Curie Hospital, Department of Translational Research, Orsay, France

Tumor resistance to radiotherapy is often associated with enhanced DNA repair activity. Short and stabilized DNA molecules (Dbait) have been recently proposed as efficient strategy to inhibit DNA repair in tumor. Dbait is thus a serious candidate to sensitize tumor to RT. Here, we use Dbait coupled with cholesterol (CoDbait) to sensitize rat orthotropic glioma to a fractionated radiotherapy. We characterize the effect of several treatment combinations on animal survival. We further analyze the growth and the microvascular properties of the implanted tumor using in vivo multiparametric MRI.