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Abstract #4235

Dynamic State of Water Molecular Displacement of the Brain During the Cardiac Cycle in Idiopathic Normal Pressure Hydrocephalus

Hirohito Kan1, Tosiaki Miyati1, Naoki Ohno1,2, Mitsuhito Mase3, Harumasa Kasai4, Masaki Hara4, Yuta Shibamoto4, Kazuo Yamada3, Makoto Kawano4

1Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan; 2Department of Radiology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan; 3Department of Neurosurgery & Restorative Neuroscience, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Aichi, Japan; 4Department of Radiology, Nagoya City University Hospital, Nagoya, Aichi, Japan

To evaluate the dynamic state of water molecular displacement of the brain during the cardiac cycle in normal pressure hydrocephalus (I-NPH), we determined the change in regional displacement of the water molecules (delta-displacement) using q-space diffusion analysis, because there were many unsolved problems with this syndrome in terms of the diagnostic criteria and selection of appropriate patients for shunt surgery. Delta-displacement analysis makes it noninvasively possible to obtain dynamic state of the water molecular displacement in brain during cardiac cycle and thereby assist in the diagnosis of I-NPH.