Abstract #4236

Anatomical Characterization of Athetotic & Spastic Cerebral Palsy using Atlas-Based Analysis

Shoko Yoshida¹, Katsumi Hayakawa², Kenichi Oishi³, Susumu Mori⁴, Toyoko Kanda⁵, Yuriko Yamori⁶, Naoko Yoshida⁷, Haruyo Hirota⁷, Mika Iwami⁷, Sozo Okano⁸

¹Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Malyland, United States; ²Radiology, Kyoto City Hospital, Kyoto, Japan; ³Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States; ⁴F.M.Kirby Resarch Center for Functional Brain Imaging, Kennedy Krieger Institute; ⁵Neuropediatrics, St.Joseph Hospital for Handicapped Children, Kyoto, Japan; ⁶St. Jpseph Hospital for Handicapped Children; ⁷St. Joseph Hospital for Handicapped Children; ⁸Pediatrics, Kyoto City Hospital

We analyzed diffusion tensor imaging of children with two different types (athetotic and spastic) of cerebral palsy (CP). For quantitative evaluation of the lesion distribution and severity, we applied atlas-based whole brain segmentation (159 structures) based on large deformation diffeomorphic metric mapping (LDDMM). Z-score map and principal component analysis of fractional anisotropy (FA), mean diffusivity (MD) and volume of the 159 structures could quantitatively delineate striking difference in brain anatomy of these two CP groups. This type of comprehensive and quantitative anatomical analysis could establish a foundation for more accurate MRI-based prognosis analysis.