Shoko Yoshida1, Katsumi Hayakawa2,
Kenichi Oishi3, Susumu Mori4, Toyoko Kanda5,
Yuriko Yamori6, Naoko Yoshida7, Haruyo Hirota7,
Mika Iwami7, Sozo Okano8
1Department of Radiology
& Radiological Science, Johns Hopkins University School of Medicine,
Baltimore, Malyland, United States; 2Radiology, Kyoto City
Hospital, Kyoto, Japan; 3Department of Radiology &
Radiological Science, Johns Hopkins University School of Medicine, Baltimore,
MD, United States; 4F.M.Kirby Resarch Center for Functional Brain
Imaging, Kennedy Krieger Institute; 5Neuropediatrics, St.Joseph
Hospital for Handicapped Children, Kyoto, Japan; 6St. Jpseph
Hospital for Handicapped Children; 7St. Joseph Hospital for
Handicapped Children; 8Pediatrics, Kyoto City Hospital
We analyzed diffusion tensor imaging of children with two different types (athetotic and spastic) of cerebral palsy (CP). For quantitative evaluation of the lesion distribution and severity, we applied atlas-based whole brain segmentation (159 structures) based on large deformation diffeomorphic metric mapping (LDDMM). Z-score map and principal component analysis of fractional anisotropy (FA), mean diffusivity (MD) and volume of the 159 structures could quantitatively delineate striking difference in brain anatomy of these two CP groups. This type of comprehensive and quantitative anatomical analysis could establish a foundation for more accurate MRI-based prognosis analysis.