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Abstract #4250

Which to Choose for Volumetry: MPRAGE or SPACE?

Tomohisa Okada1, Mitsunori Kanagaki1, Akira Yamamoto1, Ryo Sakamoto1, Seiko Kasahara1, Emiko Morimoto1, Mami Iima1, Taha M. Mehemed1, Satoshi Nakajima1, Kaori Togashi1

1Diagnostic Imaging & Nuclear Medicine, Kyoto University, Kyoto, Japan

T1-weighted 3D variable flip angle turbo spin-echo sequence called, SPACE, is gradually accepted as an alternative to MPRAGE. However, which is more suitable, if any, to brain volumetry is yet to be clarified. Therefore, we conducted a comparative study of the two sequences to investigate reproducibility of volumetric measurements of gray matter (GM) and any difference in segmented GM volumes in 10 healthy subjects. MPRAGE was superior to SPACE and such region was wide-spread. Probable reasons for the difference was discussed. SPACE may not be a substitute of MPRAGE for the purpose of cortical volumetry.