Jinyuan Zhou1,2, He Zhu1,2, Michael Lim3, Silun Wang1, Alfredo Quinones-Hinojosa3, Lindsay Blair4, John Laterra4, Peter Barker1,2, Peter C. M. van Zijl1,2, Jaishri Blakeley4
1Department of Radiology, Johns Hopkins University, Baltimore, MD, United States; 2F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States; 3Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, United States; 4Department of Neurology, Johns Hopkins University, Baltimore, MD, United States
We explored the use of fast gradient- and spin-echo (GRASE) 3D APT imaging for the visualization of human brain tumors at 3 Tesla. The preliminary results show that GRASE 3D APT imaging can be performed within a clinically feasible time of ~11 minutes. APT values were significantly different between the core of the tumor and peritumoral edema, and also between high-grade and low-grade tumors. 3D APT imaging is feasible at 3T and is a promising new MRI contrast mechanism for characterizing human brain tumors.