Jinyuan Zhou1,2, He Zhu1,2,
Michael Lim3, Silun Wang1, Alfredo Quinones-Hinojosa3,
Lindsay Blair4, John Laterra4, Peter Barker1,2,
Peter C. M. van Zijl1,2, Jaishri Blakeley4
1Department of Radiology,
Johns Hopkins University, Baltimore, MD, United States; 2F.M.
Kirby Research Center for Functional Brain Imaging, Kennedy Krieger
Institute, Baltimore, MD, United States; 3Department of
Neurosurgery, Johns Hopkins University, Baltimore, MD, United States; 4Department
of Neurology, Johns Hopkins University, Baltimore, MD, United States
We explored the use of fast gradient- and spin-echo (GRASE) 3D APT imaging for the visualization of human brain tumors at 3 Tesla. The preliminary results show that GRASE 3D APT imaging can be performed within a clinically feasible time of ~11 minutes. APT values were significantly different between the core of the tumor and peritumoral edema, and also between high-grade and low-grade tumors. 3D APT imaging is feasible at 3T and is a promising new MRI contrast mechanism for characterizing human brain tumors.
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