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Abstract #4459

Effect of the Slice Profile on the T1 Measurement with Steady-State Magnetization

Jung-Jiin Hsu1

1Radiology, University of Miami School of Medicine, Miami, FL, United States

The accuracy of the T1 measurement depends on the accuracy of the flip angle (FA). The FA is non-uniform in a slice across the slice-thickness direction, which can result in serious T1 measurement error. Although it has been recognized that measuring the FA regional inhomogeneity in a volume is important, the effect of the slice profile is still less known. In this work, the slice-profile effect is studied systematically for various common experimental conditions. The results provide essential guidelines for experiment design and scan parameter selection for the T1 measurement with steady-state magnetization (e.g., DESPOT).