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Abstract #4463

Multi-Slice Look-Locker T1 Mapping for the Mouse Heart

Adrienne E. Campbell1,2, Anthony N. Price3, Bernard M. Siow1, Jack A. Wells1, Mark F. Lythgoe1, Roger J. Ordidge2

1Centre for Advanced Biomedical Imaging, Division of Medicine & Institute of Child Health, University College London, London, United Kingdom; 2Department of Medical Physics & Bioengineering, University College London, London, United Kingdom; 3Robert Steiner MRI Unit, Imaging Science Department, Hammersmith Hostpital, Imperial College London, London, United Kingdom

A time-efficient multi-slice ECG gated Look-Locker sequence is developed for multi-slice T1 mapping in the mouse heart. With this sequence, multi-slice T1 maps can be generated for the mouse heart in less than 10 minutes. Multi-slice T1 mapping was tested in phantoms and in a CD-1 mouse, and it was found that T1 measurements agreed with single-slice T1 measurements within 4% for the phantom and within 10% in vivo. This sequence will have great applicability for multi-slice arterial spin labelling perfusion measurements to study cardiac disease models.