Adrienne E. Campbell1,2, Anthony N. Price3, Bernard M. Siow1, Jack A. Wells1, Mark F. Lythgoe1, Roger J. Ordidge2
1Centre for Advanced Biomedical Imaging, Division of Medicine & Institute of Child Health, University College London, London, United Kingdom; 2Department of Medical Physics & Bioengineering, University College London, London, United Kingdom; 3Robert Steiner MRI Unit, Imaging Science Department, Hammersmith Hostpital, Imperial College London, London, United Kingdom
A time-efficient multi-slice ECG gated Look-Locker sequence is developed for multi-slice T1 mapping in the mouse heart. With this sequence, multi-slice T1 maps can be generated for the mouse heart in less than 10 minutes. Multi-slice T1 mapping was tested in phantoms and in a CD-1 mouse, and it was found that T1 measurements agreed with single-slice T1 measurements within 4% for the phantom and within 10% in vivo. This sequence will have great applicability for multi-slice arterial spin labelling perfusion measurements to study cardiac disease models.