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Abstract #4489

In Vivo Correlation of T1 & Methemoglobin in a Mouse Model of Deep Vein Thrombosis

Prakash Saha1, Marcelo E. Andia2, Ulrike Blume2,3, Bijan Modarai1, Matthew Waltham1, Alberto Smith1, Tobias Schaeffter2, Andrea J. Wiethoff2,4

1Department of Academic Surgery, Cardiovascular Division, King's College London, London, United Kingdom; 2Division of Imaging Sciences & Biomedical Engineering, King's College London, London, United Kingdom; 3Philips Healthcare, Best, Netherlands; 4Philips Healthcare, Guildford, United Kingdom

Current imaging methods cannot accurately assess the organization of deep vein thrombosis (DVT). The purpose of this study was to investigate whether the signal generated from MRI can be used to quantify thrombus organization without contrast agent and show that the accumulation of metHb correlates directly with the T1 of the thrombus.