Meeting Banner
Abstract #4498

Optimal Parameters for a Fixed Imaging Time Acquisition of Quantitative Magnetization Transfer Data

Mara Cercignani1, Gareth J. Barker2, Daniel C. Alexander3

1Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy; 2CNS, Department of Neuroimaging, King's College London, Institute of Psychiatry, London, United Kingdom; 3Centre for Medical Image computing, Department of Computer Science, UCL, London, United Kingdom

In this paper the optimal combination of acquisition parameters (including TR, imaging flip angle, amplitude and offset frequency of the saturation pulses) for quantitative magnetization transfer imaging is obtained by means of the set which gives the maximum precision of the estimated MT parameters, under the constraint of fixed total scan time. The optimisation is achieved for a number of sampling points ranging from 10 to 18 using an algorithm of an "evolutionary" type, and the optimised schemes are compared using numerical simulations and in vivo data.