Magnetic Field-Dependent Magnetisation Transfer Contrast MRI with Fast Field-Cycling

Chang-Hoon Choi^1,2, David J. Lurie¹

Magnetisation transfer contrast (MTC) MRI is normally implemented at a fixed and high magnetic field (B₀) but has only rarely been studied at a range of B₀ due to the limitations of available MRI scanners. The use of fast field-cycling with an actively frequency switchable RF coil affords the ability to determine the MT effect over a range of magnetic fields, by rapidly switching B₀ in concert with the coils resonance frequency. In this work, we used field-cycling to evaluate the MT effects of 1%, 2% and 4% agarose samples at the five different B₀ levels by measuring MT ratios.