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Abstract #4499

Magnetic Field-Dependent Magnetisation Transfer Contrast MRI with Fast Field-Cycling

Chang-Hoon Choi1,2, David J. Lurie1

1Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen, Scotland, United Kingdom; 2MR Solutions Ltd., Guildford, Surrey, United Kingdom

Magnetisation transfer contrast (MTC) MRI is normally implemented at a fixed and high magnetic field (B0) but has only rarely been studied at a range of B0 due to the limitations of available MRI scanners. The use of fast field-cycling with an actively frequency switchable RF coil affords the ability to determine the MT effect over a range of magnetic fields, by rapidly switching B0 in concert with the coils resonance frequency. In this work, we used field-cycling to evaluate the MT effects of 1%, 2% and 4% agarose samples at the five different B0 levels by measuring MT ratios.