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Abstract #4500

Magic Angle Effects on T2, T2* & T1p Relaxation Times

Jiang Du1, Eric Diaz1, Won Bae1, Sheronda Statum1, Nikolaus Szeverenyi1, Darryl DLima2, Graeme Bydder1, Christine Chung1

1Radiology, University of California, San Diego, San Diego, CA, United States; 2Scripps Reseach Institution, San Diego, CA, United States

The early stages of OA are associated with breakdown of collagen, decrease in proteoglycans (PG) and increase in water content (1). Recent research has focused on establishing correlations between quantitative MR parameters (T1, T2, T2*, T1ρ) and biochemical or biophysical properties of cartilage. Magic angle effects influence apparent T2 values of tissues with ordered collagen structure, such as articular cartilage, menisci, ligaments and tendons. The purpose of this study was to evaluate the effect of sample orientation on T2/T2* and T1ρ values of the deep radial layer of human patellar cartilage and ligaments.