Sonya Bells1, Sean Deoni2,3,
Ofer Pasternak4, Derek K. Jones1
1CUBRIC, School of
Psychology, Cardiff, United Kingdom; 2School of Engineering, Brown
University, Providence, RI, United States; 3Centre of Neuroimaging
Sciences-Institute of Psychiatry, King's College, London, United Kingdom; 4Brigham
& Women's Hospital, Harvard Medical School, Bostan, MA, United States
Multi-component relaxometry of fast- and slow-T1 and T2 has previously been used to quantify aspects of tissue microstructure in brain tissue, notably the myelin water fraction (MWF). The myelin water content is estimated by attributing the short T2 relaxation component to the water trapped within the myelin sheath. However, the amount of partial volume contamination from cerebral spinal fluid (CSF) is unknown and until now. Here, We investigate the effects of partial volume contamination due to CSF and propose a novel approach to correcting the problem of partial volume errors in mapping myelin water content.